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☆ First Pill for Dengue Shows Promise in Human Challenge Trial
  + stars: | 2023-10-20 | by ( Oct. | At A.M. | ) www.usnews.com   time to read: +3 min
By Jennifer Rigby(Reuters) - A pill for dengue fever developed by Johnson & Johnson appeared to protect against a form of the virus in a handful of patients in a small human challenge trial in the United States, according to data presented by the company on Friday. In human challenge trials, researchers intentionally expose healthy volunteers to a pathogen to test a vaccine or treatment, or better understand the disease they cause. Dengue fever, while often asymptomatic, is also known as “break bone fever” for the severity of the joint pain and spasms that some patients experience. In the trial done with Johns Hopkins Bloomberg School of Public Health, 10 volunteers were given a high dose of the J&J pill five days before being injected with a type of dengue. The five people in a placebo group, who were also injected with dengue, all showed detectable virus when tested.
Persons: Jennifer Rigby, Johnson, Van Loock, J’s Janssen, Jeremy Farrar, Johns, J, “, ”, Bill Berkrot Organizations: Reuters, Johnson, American Society of Tropical Medicine, Hygiene, J, Health Organization’s, Johns Hopkins Bloomberg School of Public Health, WHO Locations: United States, Chicago, Asia, Latin America
☆ A tropical parasite, passed through the bite of a sand fly, is causing skin infections in the US
  + stars: | 2023-10-19 | by ( Brenda Goodman | ) edition.cnn.com   time to read: +7 min
Sand flies are tiny tan flies — about the quarter of the size of a mosquito — that live in warm, wet, rural and forested areas. These patients all had leishmaniasis skin infections, which start with a small bump that erupts into ulcerous sores days to weeks after a sand fly bite. Like other types of insects that are finding new habitats as the climate warms, sand flies have been expanding their range in recent years. It’s not clear whether sand flies in all these states have transmitted infections to humans, however. When sand flies bite the infected rats, they can pick up the parasite and then pass it to humans.
Persons: you’ve, ”, Mary Kamb, Kamb, ” Kamb, leishmaniasis, Muhammed Abdullah, Luiz Oliveira, “ It’s, ” Oliveira, It’s, Pedro Cecilio, Gideon Wasserberg, Wasserberg, Dr, Sanjay Gupta, there’s, permethrin Organizations: CNN, US Centers for Disease Control, American Society of Tropical Medicine, Hygiene, Anadolu Agency, Getty, CDC, National Institutes of Health, World Health Organization, NIH, University of North, CNN Health, US Food and Drug Administration Locations: Atlanta, United States, Syria, Texas, Oklahoma, U.S, Delaware , New Jersey , Ohio, Maryland, Chicago, Puerto Rico, Virgin, mexicana, University of North Carolina, Greensboro
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